Thrust Area 3: Fast and Uniform Rewarming
Thrust Area 3 tackles the challenges associated with the rewarming step of the biological systems to functional temperatures after cryopreservation, such as the mechanical stresses that arise due to inhomogeneous rewarming and the spontaneous ice recrystallization that can occur if samples are rewarmed too slowly. The goal is to rewarm systems rapidly enough to “outrun” ice formation and uniformly enough to prevent thermal gradients, even in systems as large as whole human organs.
The underlying physical property that governs the speed and uniformity of the rewarming process is heat transfer which is heavily size-dependent. Different technologies have been developed in the course of the last years and optimized across all testbeds.
Thrust Area 3 is supported by 12 projects involving researchers primarily at UMN, TAMU, UC Riverside and CMU, along with MGH and UC Berkeley. All 13 projects focus on achieving progress in:
Nanomaterial and EM optimization
Novel rewarming techniques for micro to millimeter systems
Photonic rewarming
RF rewarming
Rat kidney vitrification and transplantation
John Bischof lab, UMN
Temperature indicator for food storage
Yadong Yin lab, UC Riverside
Laser beam splitting setup for photonic
rewarming of biosystems
Guillermo Aguilar lab, TAMU
Robotics handling of organisms for vitrification
Michael McAlpine lab, UMN
Guillermo Aguilar (TAMU)
Thrust Area 3 Co-Lead
Zonghu Han (MGH)
Thrust Area 3 Co-Lead