About Convergent Research

Convergent Research Overview

The 20th century learned how to move information at the speed of light. The 21st century must learn how to move life across time

Mission

To develop the scientific and technological foundations that make biological time controllable.

ATP-Bio advances convergent research to safely pause metabolism through subzero cooling, preserve structural and functional integrity across biological scales, and reliably restore complex living systems. By integrating biology, physics, engineering, and systems design, we aim to create scalable preservation technologies that enable storage, transport, and global deployment of living biological materials.

Vision

A world where access to living biological systems is no longer limited by time or geography.

In this future, preservation functions as foundational infrastructure for humanity—enabling off-the-shelf regenerative therapies, resilient food systems, safeguarded biodiversity, and equitable global distribution of critical biological resources. Biological materials can be stored, moved, and reanimated with the same reliability that defines modern information and supply networks.

The grand challenges we need to overcome

Most biological systems do not survive even simple freezing and thawing. Achieving functional recovery after cryopreservation—and building an integrated cryosupply chain—requires overcoming fundamental scientific and technological barriers.

  • At the fundamental level
    • Ice formation and recrystallization damage
    • Cryoprotectant toxicity
    • Thermal and mechanical stress
    • Mitochondrial and metabolic dysfunction
    • Genetically modified systems
  • At the technological and systems level:
    • Automation and high-throughput processing
    • Quantitative assessment of viability and function
    • Scaling in volume (liters) and duration (months to years)
    • Integration of cooling and rewarming technologies
    • Quality assurance for off-the-shelf availability
    • Regulatory pathways and public acceptance
    • Equitable global allocation of scarce biological resources


Each challenge represents a fundamental barrier to safe, reliable preservation, distribution and utilization of living systems.

Strategy: A Convergent Research Approach

Biopreservation is not a single-discipline problem. It requires the integration of biology, physics, engineering, computation, and systems design.

ATP-Bio brings together multidisciplinary teams across partner institutions to address preservation as a system-level challenge. Through a convergent research model, we integrate biological, physical, and engineering systems at the critical interfaces where innovation emerges.

Our work is organized around:

Shared Challenges—cross-scale problems spanning cells to organs.

Collaborative Teams—coordinated, cross-institutional groups aligned toward common translational objectives.

Iterative Design & Testing—continuous cycles from theory to engineered platforms to real biological testbeds.

Building on this foundation, ATP-Bio is evolving from a discovery-driven effort into a translation-focused ecosystem that connects science, engineering, and society. This approach accelerates innovation while ensuring scalability and real-world impact.

The Global Impact We Aim to Achieve

  • Discover novel methods to preserve biological systems by pausing metabolism through subzero cooling.
  • Develop scalable, reproducible technologies for safe cooling and rewarming of biological materials.
  • Translate preservation innovations into practical tools for use in medicine, agriculture, and conservation.
  • Build a collaborative, cross-institutional research ecosystem that accelerates technology deployment.
  • Maximize societal impact by enabling a cryosupply chain combining storage and delivery of critical biological resources globally.

CONVERGENT RESEARCH

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