Thrust Area 2

Thrust Area 2: Multi-Scale Thermodynamics of Water

Thrust Area 2 supports the ability to cryopreserve biological systems by preventing and/or mitigating ice crystallization of their water content during the cooling process even in systems as cold as -150 ºC, through strategic use of CPAs and manipulating the cooling conditions themselves. Three cryopreservation regimes are studied in ATP-Bio projects.

Thrust Area 2 overviews 15 projects involving researchers at MGH, UMN, UC Berkeley, TAMU, and UC Riverside of which many are interinstitutional. TA2 aims to reach success in the following milestones:

  • Controlling the phase change of water
  • Supercooling up to 2 L
  • Partial freezing and vitrification up to 100 mL
  • Isochoric biopreservation
Cryopreservation Regimes
Cardiac Mps About To Undergo Isochoric Cooling
Kevin Healy lab, UC Berkeley
Outputs Of The Extreme Value Statistical Model Of Heterogeneous Ice Nucleation
Matthew Powell-Palm lab, TAMU
3D Cryoprinter
Rubinsky lab, UC Berkeleygun lab, MGH

CR ACTIVITIES

Boris Rubinsky : Thrust Area 2 Co-Lead

Boris Rubinsky

Thrust Area 2 Co-Lead
REBECCA SANDLIN (MGH) : Thrust Area 2 Co-Lead

REBECCA SANDLIN (MGH)

Thrust Area 2 Co-Lead